Acamprosate and naltrexone, individually or in combination, for the treatment of alcohol dependence
نویسنده
چکیده
The findings of the COMBINE Study have recently been published (Anton et al 2006). The COMBINE Study is a major, multisite RCT of acamprosate and naltrexone in conjunction with behavioural treatment. As such this study has the potential to significantly influence treatment of alcohol dependence. This brief critical appraisal of the COMBINE Study has been prepared to assess its implications in terms of the overall effectiveness of acamprosate and naltrexone for the treatment of alcohol dependence.
منابع مشابه
New pharmacotherapies for alcohol dependence.
Two pharmacotherapies recently introduced in Australia, acamprosate and naltrexone, provide a major advance in the treatment of severe alcohol dependence, a common condition leading to a considerable burden of illness and major costs to the community. Acamprosate and naltrexone reduce alcohol intake, and increase the likelihood and prolong the duration of abstinence (Level I evidence). Compared...
متن کاملAlcoholism – the Worst Addiction
Introduction: The most common substance of abuse/dependence in patients presenting for treatment in western countries is alcohol. Ethyl alcohol or ethanol which is also called medicinal alcohol is used as an official drug compendium. It is also administered as an antidote in methanol poisoning. However, regular consumption of high amounts of alcoholic drinks induces dependence and addiction lea...
متن کاملEfficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence: a systematic review.
AIMS To ascertain the efficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence. METHODS Systematic review of the literature (1990-2002) and meta-analysis of full published randomized and controlled clinical trials assessing acamprosate or naltrexone therapy in alcohol dependence. Estimates of effect were calculated according to the fixed-effects model. MEASUR...
متن کاملNaltrexone versus acamprosate: one year follow-up of alcohol dependence treatment.
Naltrexone and acamprosate reduce relapse in alcohol dependence. They have not yet been compared in a published trial. The aim of this study was to compare the efficacy of these compounds in conditions similar to those in routine clinical practice. Random allocation to a year of treatment with naltrexone (50 mg/day) or acamprosate (1665-1998 mg/day) was made in 157 recently detoxified alcohol-d...
متن کاملLong-term drug treatment of patients with alcohol dependence.
Drug therapy for alcohol dependence should only be used in conjunction with a comprehensive treatment plan. Naltrexone and acamprosate have well established efficacy and are first-line treatments. Naltrexone is recommended for patients aiming to cut down their alcohol intake who do not have severe liver disease or an ongoing need for opioids. Acamprosate is recommended for those who have achiev...
متن کامل